Kenneth K Wu Selected Research

5-methoxytryptophan

10/2021	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma.
1/2021	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite.
10/2019	Tryptophan metabolite 5-methoxytryptophan ameliorates arterial denudation-induced intimal hyperplasia via opposing effects on vascular endothelial and smooth muscle cells.
1/2018	Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression.
11/2016	5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility.
5/2016	Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan.
1/2016	A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury.
1/2016	Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation.
8/2012	Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan.

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Kenneth K Wu Research Topics

Disease

16	Atherosclerosis 01/2015 - 02/2002
13	Inflammation (Inflammations) 07/2020 - 06/2002
12	Neoplasms (Cancer) 10/2021 - 05/2005
9	Coronary Disease (Coronary Heart Disease) 06/2008 - 02/2002
5	Infarction (Infarctions) 01/2021 - 04/2002
5	Thrombosis (Thrombus) 05/2011 - 05/2003
5	Stroke (Strokes) 02/2008 - 04/2002
4	Carcinogenesis 03/2014 - 08/2002
4	Flushing 03/2010 - 04/2006
3	Breast Neoplasms (Breast Cancer) 10/2021 - 05/2005
3	Neoplasm Metastasis (Metastasis) 04/2021 - 05/2016
3	Fibrosis (Cirrhosis) 01/2021 - 07/2020
3	Myocardial Infarction 11/2016 - 11/2008
3	Heart Failure 11/2016 - 03/2004
3	Hyperglycemia 01/2015 - 08/2005
3	Colonic Neoplasms (Colon Cancer) 02/2010 - 05/2005
3	Ischemia 03/2009 - 04/2002
3	Ischemic Stroke 07/2006 - 11/2005
2	Liver Neoplasms (Liver Cancer) 04/2021 - 05/2005
2	Lung Neoplasms (Lung Cancer) 01/2020 - 05/2005
2	Vascular Diseases (Vascular Disease) 01/2016 - 01/2016
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2015 - 05/2002
2	Reperfusion Injury 01/2010 - 03/2009
2	Cerebral Infarction 03/2009 - 04/2002
2	Dyslipidemias (Dyslipidemia) 04/2006 - 08/2005
1	Hepatocellular Carcinoma (Hepatoma) 10/2021
1	Hypertrophy 01/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021
1	Hyperplasia 10/2019
1	Ventricular Remodeling 11/2016
1	ST Elevation Myocardial Infarction 11/2016
1	Neointima 01/2016
1	Vascular System Injuries 01/2016
1	Sepsis (Septicemia) 01/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2013
1	Atherosclerotic Plaque (Atheroma) 01/2013
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2012
1	Leukemia 03/2012
1	Dysbiosis 03/2012

Drug/Important Bio-Agent (IBA)

11	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2016 - 06/2002
9	5-methoxytryptophanIBA 10/2021 - 08/2012
8	Tryptophan (L-Tryptophan)FDA Link 10/2021 - 03/2014
5	Proteins (Proteins, Gene)FDA Link 05/2016 - 04/2002
5	ThrombomodulinIBA 02/2012 - 04/2003
4	ProstaglandinsIBA 01/2014 - 04/2002
4	Niacin (Nicotinic Acid)FDA LinkGeneric 03/2010 - 04/2006
3	Biomarkers (Surrogate Marker)IBA 10/2021 - 11/2016
3	Acetylserotonin O-Methyltransferase (Hydroxyindole O Methyltransferase)IBA 10/2021 - 01/2018
3	LipidsIBA 01/2013 - 08/2005
3	EnzymesIBA 08/2012 - 08/2002
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2009 - 04/2007
3	C-Reactive ProteinIBA 07/2006 - 08/2002
3	Hemostatics (Antihemorrhagics)IBA 07/2006 - 05/2002
2	Caspase 3 (Caspase-3)IBA 01/2021 - 03/2006
2	5-methoxyindoleIBA 01/2016 - 03/2014
2	LipopolysaccharidesIBA 01/2016 - 04/2011
2	AntigensIBA 01/2015 - 01/2014
2	Apolipoproteins E (ApoE)IBA 01/2013 - 08/2005
2	Platelet Membrane GlycoproteinsIBA 04/2011 - 02/2004
2	LigandsIBA 04/2011 - 03/2009
2	P-SelectinIBA 04/2011 - 05/2006
2	Rosiglitazone (Avandia)FDA Link 03/2009 - 03/2006
2	PPAR gammaIBA 03/2009 - 03/2006
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2009 - 03/2004
2	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2009 - 04/2002
2	PPAR deltaIBA 01/2009 - 04/2007
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/2008 - 05/2003
2	Fibrinogen (Factor I)FDA Link 06/2008 - 07/2006
2	Plasminogen Activators (Plasminogen Activator)IBA 06/2008 - 07/2006
2	Thromboxane Receptors (Thromboxane Receptor)IBA 04/2007 - 07/2004
2	Cyclooxygenase 1IBA 03/2006 - 04/2002
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 08/2003 - 04/2003
1	Messenger RNA (mRNA)IBA 10/2021
1	p38 Mitogen-Activated Protein KinasesIBA 04/2021
1	Serotonin (5 Hydroxytryptamine)IBA 04/2021
1	triphenyltetrazoliumIBA 01/2021
1	Troponin IIBA 01/2021
1	Succinic Acid (Succinate)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2018
1	VimentinIBA 05/2016
1	Cadherins (E-Cadherin)IBA 05/2016
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016
1	Conditioned Culture MediaIBA 01/2016
1	CytokinesIBA 01/2016
1	EndotoxinsIBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2015
1	Oxidants (Oxidizing Agents)IBA 01/2015
1	MelatoninIBA 03/2014
1	Oxidoreductases (Dehydrogenase)IBA 01/2013
1	Toll-Like Receptor 2IBA 11/2012
1	Pharmaceutical PreparationsIBA 08/2012
1	Methotrexate (Mexate)FDA LinkGeneric 03/2012
1	LectinsIBA 02/2012

Therapy/Procedure

6	Therapeutics 04/2021 - 05/2003
2	Chemoprevention 04/2021 - 03/2014
1	Ligation 01/2016
1	Cell Transplantation 12/2015
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2015
1	Drug Therapy (Chemotherapy) 03/2012